- How do memory systems in the medial temporal lobe interact with executive systems in the prefrontal cortex to guide adaptive behavior at the computational, cellular, and circuit levels?
- What are the causal roles of specific projection pathways connecting the hippocampus and medial prefrontal cortex, particularly disynaptic thalamic and cortical routes?
- What neural representations and computations go awry in disorders related to dysfunction in a hippocampus-prefrtonal cortex system including schizophrenia, ADHD, and Alzheimer’s disease, and lead toxicity?
Current Research Programs:
- The role of direct, thalamic, and cortical projections between the hippocampus and prefrontal cortex in memory for sequences of events in rats and humans.
- The role of midline thalamic and cortical projections from the prelimbic region of the prefrontal cortex to the hippocampus in temporal reward discounting in rats and humans.
- The neural representations of time in the nucleus reuniens of the thalamus in rats using a bi-peak response procedure.
- Identification and function of the “limbic thalamus” in humans, including the nucleus reuniens and rhomboid nucleus using probabilistic tractography.
- The effects of chronic lead exposure on hippocampal-prefrontal interactions and representations.