Overarching Questions:

  1. How do memory systems in the medial temporal lobe interact with executive systems in the prefrontal cortex to guide adaptive behavior at the computational, cellular, and circuit levels?
  2. What are the causal roles of specific projection pathways connecting the hippocampus and medial prefrontal cortex, particularly disynaptic thalamic and cortical routes?
  3. What neural representations and computations go awry in disorders related to  dysfunction in a hippocampus-prefrtonal cortex system including schizophrenia, ADHD, and Alzheimer’s disease, and lead toxicity?

Current Research Programs:

  1. The role of direct, thalamic, and cortical projections between the hippocampus and prefrontal cortex in memory for sequences of events in rats and humans.
  2. The role of midline thalamic and cortical projections from the prelimbic region of the prefrontal cortex to the hippocampus in temporal reward discounting in rats and humans.
  3. The neural representations of time in the nucleus reuniens of the thalamus in rats using a bi-peak response procedure.
  4. Identification and function of the “limbic thalamus” in humans, including the nucleus reuniens and rhomboid nucleus using probabilistic tractography.
  5. The effects of chronic lead exposure on hippocampal-prefrontal interactions and representations.

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